Actonel

This page contains recent news articles, when available, and an overview of Actonel but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Actonel
(when available)

Pharmacology and use:
Risedronate is a pyridinyl bisphosphonate that inhibits osteoclast-mediated bone resorption and modulates bone metabolism and is indicated for the treatment and prevention of osteoporosis in postmenopausal women. For the treatment of Paget's disease of the bone (osteitis deformans); Postmenopausal and glucocorticoid-induced osteoporosis

Mechanism Of Action:
The action of Risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

News Articles on Risedronate

Options for Bone Loss, but No Magic Pill  -  04 Jan 2010
Likewise with a sister drug, Actonel (risedronate). A reluctance on the part of many patients to adhere to a daily or weekly regimen led to the development ... New York Times

Vitamin D can help with bone density and immunity  -  04 Jan 2010
I took Actonel but developed leg cramps. I took one Boniva tablet the nurse gave me as a sample, but I now have unbearable indigestion. ... Los Angeles Times

Studies: Bone drugs may help prevent breast cancer  -  ‎Dec 10, 2009‎
SAN ANTONIO — New results from a landmark women's health study raise the exciting possibility that bone-building drugs such as Fosamax and Actonel may help ... The Associated Press

Bone Drugs May Lower Risk for Breast Cancer  -  ‎Dec 12, 2009‎
New results from a landmark women's health study raised the exciting possibility that bone-building medications such as Actonel and Fosamax may help lower ... HealthNews

Bone density drugs may prevent breast cancer  -  ‎Dec 28, 2009‎
A new study has revealed that bisphosphonates like Fosamax and Actonel taken by women may play a key role in preventing breast cancer. ... Biomed Middle East

Economic news raises hopes for global recovery  -  ‎Dec 11, 2009‎
...results from a landmark women's health study raise the possibility that bone-building drugs such as Fosamax and Actonel may help prevent breast cancer. ... The Spokesman Review

Medicare Part D  -  ‎Dec 13, 2009‎
But when I went to the Unicare site and entered other clients' drug lists, I discovered this plan doesn't cover drugs such as Actonel, Aciphex, and Crestor. ... Tucson Citizen

Health Matters: Bone-Strengthening Drugs Helping Breast Cancer?  -  ‎Dec 15, 2009‎
Scientists looked at drugs including Fosamax, Actonel and Boniva -- and their affect on post-menopausal women. The lead researcher, at the Los Angeles ... WCTV

Warner Chilcott: An Undervalued Growth Play  -  ‎Dec 21, 2009‎
The company's diversified portfolio of branded products include popular names like Actonel and Asacol, which generated over $2 billion in sales last year. ... Sumfolio.com

Osteopororosis reversing drugs may prevent breast cancer  -  ‎Dec 12, 2009‎
Data drawn from the ongoing Women's Health Initiative suggests that bone-building drugs (bisphosphonates) such a Fosamax®, Boniva®, and Actonel® may not ... Examiner.com

Many Sources of Upside for WCRX  -  ‎Dec 9, 2009‎
Asacol and Actonel would be converted into versions with longer patent lives. Morgan Stanley expects WCRX's SG&A expenses to decline during 2015, ... Benzinga

Thinning Bones? How to Tell if You Need an Osteoporosis Medication  -  ‎Dec 30, 2009‎
...but many women in the latter category, experts contend, are being unnecessarily treated with bisphosphonate drugs like Boniva, Fosamax, or Actonel. ... U.S. News & World Report (blog)

OTC, Personal Care Are Heating Up Again  -  ‎Dec 23, 2009‎
...dream of more than two decades to build a prescription-drug business when it divested a portfolio that included Actonel and Enablex to Warner Chilcott. ... AdAge.com (subscription)

Today's Lady News: Houston Might Elect A Lesbian Mayor!  -  ‎Dec 10, 2009‎
...[New York Times Magazine] A study of 151000 women in the Women's Health Initiative found that those who took bone-building drugs, like Fosamax and Actonel, ... The Frisky

VICKS® HAS INTRODUCED DAYQUIL® MUCUS CONTROL TM AND DAYQUIL® MUCUS CONTROL TM DM  -  ‎Dec 23, 2009‎
Dawn®, Gain®, Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, and Braun®. ... PR Newswire (press release)

Merck loses effort to dismiss 24 Fosamax cases  -  ‎Dec 11, 2009‎
Fosamax belongs to the bisphosphonate family of osteoporosis drugs that include Procter & Gamble Co's Actonel and Roche Holding AG's Boniva. ... The Gazette (Montreal)

Drugs may increase risk for falls  -  ‎Dec 15, 2009‎
Physicians who prescribe bone-building drugs like Actonel, Boniva and Fosamax also should be cautious about prescribing medications that might increase the ... The Spokesman Review

Legal fight fails as NICE stands firm on osteoporosis guidance  -  ‎Dec 10, 2009‎
...with Procter & Gamble's Didronel (etidronate) and Actonel (risedronate) as first alternatives if the patient is intolerant to Fosamax. ... Pharma Times

European experts recommend Amgen, Glaxo bone drug  -  ‎Dec 18, 2009‎
VX) Zometa; Actonel from Sanofi-Aventis (SASY.PA) and Procter & Gamble (PG.N); and Glaxo's own product Boniva or Bonviva, which it sells with Roche (ROG. ... Reuters

Warner Chilcott Affirms Global Marketing and Collaboration Agreement With ...  -  ‎Dec 15, 2009‎
...between a P&G subsidiary acquired by Warner Chilcott and Sanofi relating to the development and sale of risedronate products (including Actonel®). ... CNNMoney.com (press release)

Golden Globe-Nominated Actress Gabourey Sidibe Visits Duracell Smart Power Lab ...  -  ‎Dec 31, 2009‎
Bounty, Dawn, Gain, Pringles, Charmin, Downy, Lenor, Iams, Crest, Oral-B, Actonel, Duracell, Olay, Head & Shoulders, Wella, Gillette, Braun and Fusion. ... India Business Blog (blog)

Warner Chilcott Considers Potential Repurchase or Redemption of 8.75% Senior ...  -  ‎Dec 14, 2009‎
...acquired by Warner Chilcott and Sanofi-Aventis US LLC ("Sanofi") relating to the development and sale of risedronate products (including Actonel®). ... Melodika.net

Fármacos para osteoporosis reducen riesgo cáncer de mama:estudio  -  ‎Dec 11, 2009‎
Otros fármacos del mismo tipo son Boniva de Roche y Actonel que es vendido por Procter & Gamble Co.. "La idea de que los bifosfonatos puedan reducir la ... Reuters América Latina

Europe - Recommandation favorable pour le denosumab d'Amgen  -  ‎Dec 18, 2009‎
VX: Cotation), l'Actonel de Sanofi-Aventis (SASY.PA: Cotation) et Procter and Gamble (PG.N: Cotation) et le Boniva ou Bonviva de Glaxo, commercialisé avec ... Reuters

골다공ì¦?약 복용 여성, 유방암 위험 ê°?소해  -  ‎Dec 10, 2009‎
...ê°™ì?€ 비스í?¬ìФí?¬ë„¤ì?´íЏ 계열 약물로는 로슈ì?˜ '보니바(Boniva)'와 P&Gì?˜ '악토넬(Actonel)'등ì?´ 있다. 현재 미국ì—?서는 매년 3천만건ì?˜ 비스í?¬ìФí?¬ë„¤ì?´íŠ¸ê³„ì—´ 약물ì?´ ... 데일리팜

Medicametele pentru osteoporoza previn cancerul la san  -  ‎Dec 12, 2009‎
Este vorba despre Fosamax si Actonel, ambele din familia bisfosfonatilor, despre care studiile au aratat ca previn cancerul la san, mai cu seama tipurile ... Ziare.com

Препараты длÑ? укреплениÑ? коÑ?тей предотвращают рак молочной железы  -  ‎Dec 12, 2009‎
Ð?едавнее иÑ?Ñ?ледование, проведенное американÑ?ким учеными, показало, что два препарата длÑ? укреплениÑ? коÑ?тей и поÑ?троениÑ? коÑ?тной маÑ?Ñ?Ñ‹ “Fosamaxâ€? и “Actonelâ€? ... Lenta.co.il

Markentransfer bei Procter & Gamble als strategische Option  -  ‎Dec 29, 2009‎
Beispiele sind: Actonel, Always, Ariel, blend-a-dent, blend-a-med, Blendax, Hugo Boss Parfüm, Zewa Wisch & Weg, Braun, Bruno Banani Parfüm, ... Deutsche Wirtschaft AG

Osteoporosis drugs pose extraction risk  -  14 Nov 2009
Rose Dear Rose: Fosamax, Boniva, and Actonel are known as bisphosphonates and have been prescribed by physicians since the 1990s to combat osteoporosis. ... Reading Eagle

Health Alliance Announces Promising Nine-Month Results from First Ever Outcome ...  -  ‎Oct 29, 2009‎
Through the program with Health Alliance, the makers of Actonel agreed to reimburse a maximum number of non-spinal osteoporotic fractures per 1000 patients ... Reuters

Warner Chilcott closes $3.1B buyout of P&G unit  -  ‎Oct 30, 2009‎
With the deal, Warner Chilcott gains a portfolio of products worth about $2.3 billion in annual revenue including blockbuster osteoporosis drug Actonel. ... Forbes

Sanofi-Aventis adj net profit up 16%, ups guidance  -  ‎Oct 30, 2009‎
Excluding amortization charges against intangible assets, impairment losses on drugs Benzaclin, Nasacort and Actonel, and deferred taxes, it would have ... MarketWatch

Procter & Gamble Financial Gauge Analysis for September 2009 Quarter  -  ‎Nov 3, 2009‎
...sells well-known consumer products, including Pampers, Tide, Ariel, Always, Pantene, Bounty, Pringles, Charmin, Downy, Iams, Crest, Actonel and Olay. ... Seeking Alpha (blog)

P&G First Quarter Sales and EPS Exceed Expectations  -  ‎Oct 29, 2009‎
Net earnings decreased one percent primarily due to lower net sales, partially offset by the gain on the sale of Actonel in Japan, which was included in net ... Reuters

Ask Dr. H: Pain in feet could be neuropathic  -  ‎Oct 19, 2009‎
I'm 85 years old, and take Synthroid, Diovan, Zocor, Coreg CR, Actonel, and a baby aspirin. Answer: It's difficult to say for certain why you've got ... Philadelphia Inquirer

SunEdison and Procter & Gamble Activate 1.1 MW Solar PV System at Paper ...  -  ‎Nov 11, 2009‎
Downy ® , Lenor ® , Iams ® , Crest ® , Oral-B ® , Actonel ® , Duracell ® , Olay ® , Head & Shoulders ® , Wella ® , Gillette ® , Braun ® , and Fusion ® . ... WELT ONLINE

Tide Introduces the Tide Stain Brain Mobile Application for iPhone and iPod Touch  -  ‎Nov 11, 2009‎
Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. ... CNNMoney.com (press release)

Video: Hundreds Line Up for Charmin(R) Open Auditions to Work in Times Square ...  -  ‎Nov 5, 2009‎
Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. ... Reuters

Cheer(R) Launches New Soap Opera Campaign Featuring All My Children's Cameron ...  -  ‎Nov 5, 2009‎
Folgers®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Gain®. ... Reuters

Procter & Gamble Income Statement Analysis for September 2009 Quarter  -  ‎Oct 29, 2009‎
Charmin, Downy, Iams, Crest, Actonel and Olay. P&G's Revenue was 5.6 percent less than the restated value for Revenue in the September 2008 quarter. ... Seeking Alpha (blog)

Popular Mom Bloggers Pen New Humor Book About Modern Motherhood, Hit The Road ...  -  ‎Nov 5, 2009‎
Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. ... Reuters

Duracell Unveils New Battery With Gauge Showing Power Levels  -  ‎Nov 5, 2009‎
Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. ... Reuters

Video: Oral-B Stages Helps Parents Preserve Their Children's Beautiful Smiles ...  -  ‎Nov 2, 2009‎
Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. ... Reuters

P&G's Always and Beinggirl.com Announce 'America's Biggest Sleepover' With 19 ...  -  ‎Oct 29, 2009‎
Bounty®, Dawn®, Pringles®, Folgers®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella, Gillette®, ... Reuters

New Interactive 3D Molecular Images in Scientific Articles  -  ‎Oct 19, 2009‎
As soon as the drug company, Proctor & Gamble, looked at the protein, known as FDPS, using iSee, they understood immediately how their drug Actonel (also ... ScienceBlogs (blog)

Bounty and Russell Simmon's Rush Philanthropic Arts Foundation Unveil National ...  -  ‎Oct 29, 2009‎
Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. ... Reuters

Swine flu shot may ease pregnant mom's worries  -  ‎Nov 2, 2009‎
Parathyroid hormone and medications like Fosamax, Boniva and Actonel may also be helpful for treatment of compression fractures and their prevention. ... Milwaukee Journal Sentinel

Academic made 'untrue' declaration about 'full access' to research material ...  -  ‎Nov 10, 2009‎
...stated in a paper on the osteoporosis drug Actonel that he had been given “full access to the data and analyses� on which his conclusions were based. ... Times Higher Education

Crown Crafts Expands Its Reach With a Known and Trusted Parenting Brand  -  ‎Oct 27, 2009‎
Pringles®, Folgers®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Wella®, Head & Shoulders®, Gillette® and Braun®. ... Reuters

National osteoporosis day, a day of awareness  -  ‎Oct 20, 2009‎
This includes Fosamax, Actonel and Boniva taken orally; and Boniva and Reclast taken intravenously. Each drug has its pluses and minuses and the choice ... Post Searchlight

Procter & Gamble Releases 11th Annual Sustainability Report  -  ‎Oct 19, 2009‎
Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. ... Reuters

Vicks to Send a Lucky Fan to Cheer on Team USA at the 2010 Olympic Winter Games!  -  ‎Oct 19, 2009‎
Dawn®, Gain®, Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, and Braun®. ... Reuters

Sanofi-aventis Delivers a Solid Performance in Third Quarter 2009  -  ‎Oct 30, 2009‎
Impairment losses of euro 352 million, of which euro 344 million was booked in the third quarter, mainly in respect of Benzaclin®, Nasacort® and Actonel® in ... Reuters

Osteoporosis update  -  ‎Oct 31, 2009‎
The three most common, Fosomax, Actonel and Boniva will prevent further demineralization and even lay down new bone. All three are similar in their ... Glens Falls Post-Star

Highlights From PG's Q1 Conference Call: All-in Sales, Organic Sales, and EPS ...  -  ‎Oct 29, 2009‎
Core earnings per share, which on the quarter adjust for the gain of the sale of our Actonel business in Japan, the operating earnings of the pharmaceutical ... StreetInsider.com (subscription)

Medicine charges to rise  -  ‎Nov 6, 2009‎
The brand name for risedronate is Actonel. For alendronate, brand names include Fosax, Adronat, Alendrobell, Alendro Alendronate GA and Ossmax. Courier Mail

Reportlinker Adds Regenerative Medicines: Bone and Joint Applications  -  ‎Nov 3, 2009‎
2007-2014 ($ MILLIONS) 119 PAGET'S DISEASE 119 DRUGS CURRENTLY AVAILABLE TO TREAT PAGET'S DISEASE 120 Actonel 120 Aredia 120 Skelid 121 Zometa 121 THE ... IT News Online

Tide Introduces the Tide Stain Brain Mobile Application for iPhone and iPod Touch  -  ‎Nov 12, 2009‎
Pringles®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® and Fusion®. ... PR Newswire (press release)

Remodeling of bone leads to Paget's disease  -  ‎Oct 20, 2009‎
Medicines used for osteoporosis are used in Paget's disease — drugs like Reclast, Fosamax and Actonel. Dear Dr. Donohue — My husband died only minutes after ... St. Louis Post-Dispatch

Still Waiting for Its Blockbuster  -  ‎Oct 20, 2009‎
...(NYSE: SNY) Actonel, and even generic-drug makers that sell versions of Merck's (NYSE: MRK) Fosamax. could also be seen as a good sign for competitors. ... The Money Times

Study demonstrates once-daily dose of Asacol(R) (mesalamine) is comparable to ...  -  ‎Oct 28, 2009‎
P&G Pharmaceuticals (P&GP) has successfully developed and marketed a wide range of prescription products since the 1980s, including Actonel(R), Asacol(R), ... CNW Telbec (Communiqué de presse)

Warner Chilcott Q3 Profit Soars On Licensing Deal Gains - Update  -  ‎Nov 9, 2009‎
As per the terms of the agreement, Warner Chilcott will acquire P&G's prescription drugs including the blockbuster women's osteoporosis drug Actonel, ... Trading Markets (press release)

Parents want more dates, less diapers in Baby's first year  -  ‎Oct 19, 2009‎
Charmin(R), Downy(R), Iams(R), Crest(R), Oral-B(R), Actonel(R), Duracell(R), Olay(R), Head & Shoulders(R), Wella(R), Gillette(R), and Braun(R). ... CNW Telbec (Communiqué de presse)

沃尔玛:å°?å°?自有å“?牌ç»?è?¥çš„甜头  -  ‎Nov 1, 2009‎
...美白牙贴使得大部分消费者以25美元的低价就å?¯ä»¥è½»æ?¾ç¾Žç™½ç‰™é½¿ï¼›Actonel骨质ç–?æ?¾è?¯ç‰©è®©å¦‡å¥³åœ¨å•†åº—里就å?¯ä»¥è½»æ˜“进行骨质密度测试,而ä¸?是一定è¦?去医生办公室… ... 和讯网

æ—¥ 제네릭 시장 '외ìž?사 진출러시'  -  ‎Nov 2, 2009‎
...ìš°ì„  ë‚´ë…„ì—? '노보믹스'(NovoMix, insulin aspart), '악토넬'(Actonel, risedronate), '세레벤트'(Serevent, salmeterol), '프로그ëž?'(Prograf, tacrolimus)ì?˜ 특허가 ... 디지틀보사

P&G mit Deutschem Nachhaltigkeitspreis 2009 in der Kategorie "Deutschlands ...  -  ‎Nov 6, 2009‎
Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella®, Gillette®, Braun® und Fusion® gehören. ... news aktuell (Pressemitteilung)

Noi vedete s-au alaturat campaniei “Sansa la viata, sansa la noi amintiriâ€?  -  ‎Oct 26, 2009‎
Dawn®, Pringles®, Folgers®, Charmin®, Downy®, Lenor®, Iams®, Crest®, Oral-B®, Actonel®, Duracell®, Olay®, Head & Shoulders®, Wella, Gillette® si Braun. ... IQads

Emekliler De “Artık Yeterâ€? Dedi  -  ‎Oct 27, 2009‎
...-KEMİK ERİMESİ için kullanılan ACTONEL için önceden hiç para ödemezken ÅŸimdi 10TL fark 2TL de muayene ücreti ödenmektedir. MaaÅŸlardan kesilen %10'da cabası, ... Mücadele

Une étude prouve qu'une dose quotidienne unique d'Asacol(R) (mésalazine ...  -  ‎Oct 28, 2009‎
P&G Pharmaceutique (P&GP) élabore et commercialise avec succès une vaste gamme de produits délivrés sur ordonnance depuis les années 1980, dont Actonel(R), ... Canada NewsWire (press release)

Brand Names/Synonyms:
Actonel is also known by the following brand names and/or synonymsActonel; Pyridine N-Oxide; Pyridostigmine Bromide; Pyridostigmine Bromine; Risedronate; Risedronate Sodium; Risedronic Acid

Drug Category:
Actonel is categorized under the following by the FDA: Antiresorptives; Bisphosphonates; Antihypocalcemic Agents;

Dosage Forms:
TABLET

Absorption:
Rapid absorption (~1 hr) after an oral dose, occurs throughout the upper gastrointestinal tract

Interactions:
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Chemical IUPAC Name:
(1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonicacid





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