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Abacavir sulfateThis page contains recent news articles, when available, and an overview of Abacavir sulfate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Abacavir sulfate (when available) Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Abacavir is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. For the treatment of HIV-1 infection, in combination with other antiretroviral agents Mechanism Of Action: Abacavir is a carbocyclic synthetic nucleoside analogue. Intracellularly, Abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. News Articles on Abacavir GlaxoSmithKline, Pfizer Launches Specialist HIV Company - Nov 4, 2009 ...-ViiV Healthcare has 10 medicines currently available including therapies such as Epzicom/Kivexa (abacavir sulfate+lamivudine) and Selzentry/Celsentri ... CNNMoney.com Generic Name: Tenofovir, emtricitabine - Nov 11, 2009 Epivir or Epivir-HBV (lamivudine), Epzicom (abacavir sulfate/lamivudine), Trizivir (abacavir sulfate/lamivudine/zidovudine), or Viread because these ... Pattaya Daily News GlaxoSmithKline and Pfizer launch HIV joint venture - Nov 5, 2009 ViiV Healthcare has 10 medicines currently available including therapies such as Epzicom/Kivexa (abacavir sulfate+lamivudine) and Selzentry/Celsentri ... Trading Markets (press release) Megalakult a ViiV Healthcare - Nov 3, 2009 A ViiV Healthcare-nek jelenleg 10 gyógyszere elérhető, beleértve olyan terápiás készítményeket is, mint például az Epzicom/Kivexa (abacavir sulfate + ... Weborvos Brand Names/Synonyms: Abacavir sulfate is also known by the following brand names and/or synonyms1592U89; ABC; Abacavir; Abacavir [Inn]; Ziagen Drug Category: Abacavir sulfate is categorized under the following by the FDA: Anti-HIV Agents; Nucleoside and Nucleotide Reverse Transcriptase Inhibitors; ATC:J05AF06 Dosage Forms: SOLUTION; TABLET Absorption: Rapid and extensive after oral administration (83% bioavailability) Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: [4-(2-amino-6-cyclopropylamino-9H-purin-9-yl)-1-cyclopent-2-enyl]methanol |
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