Retinoblastoma

This page contains recent news articles, when available, and an overview of Retinoblastoma but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Retinoblastoma

Health Talk: Retinoblastoma  -  ‎Nov 1, 2009‎
CMU The Tartan OnlineRetinoblastoma is a type of cancer that develops in the retina — the lining of the eye that senses light as it comes through the front of the eye. ...

Pilot For A Day  -  ‎Nov 19, 2009‎
KIII TV3Little five year old Jacobo Fernandez from Corpus Christi, lost his eyesite while still an infant due to retinoblastoma. But his love for aviation didn't ...

RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes ...  -  ‎Nov 2, 2009‎
7thSpace Interactive (press release)The Retinoblastoma tumor suppressor (RB) participates in the regulation of synchrony between DNA synthesis and centrosome duplication and it is involved in ...

No 'Red Eye' in Photos Could Indicate Cancer  -  ‎Nov 19, 2009‎
Momlogic.comInstead, she was diagnosed with retinoblastoma, a form of eye cancer that affects about 300 kids per year in the United States. ...

"Give for Liv" Fundraiser  -  ‎Nov 1, 2009‎
Action 3 NewsShe's visited Philadelphia twice, but more than that she's battled Retinoblastoma, also known as cancer of the eye. Jessica Loghry: "You're told your ...

Ouachita Baptist science students win research awards  -  ‎Nov 11, 2009‎
Siftings HeraldNelson's project explored whether “cannabinoids could induce death in retinoblastoma cells so that they could potentially be used to treat retinoblastoma,? ...

This year more than ever, Operation Holiday needs your support  -  ‎Nov 22, 2009‎
Dailyrecord.comThe parents of two recently suffered the loss of their eldest daughter, Hillary, at the age of 21 months when she succumbed to retinoblastoma eye cancer. ...

K'NEX Brands Launches Fundraising Initiative to Benefit The children's ...  -  ‎Nov 20, 2009‎
PR Web (press release)...forefront of developing new therapies to treat pediatric leukemia and other blood disorders, brain tumors, sarcomas, retinoblastoma, and neuroblastoma. ...

Health Matters : What is Hyphema ?  -  ‎Nov 7, 2009‎
PR-Inside.com (Pressemitteilung)Retinoblastoma and melanoma, cancers which can affect the eye, may sometimes bleed from the tumor tissue producing a hyphema. Inspection of the eye shows a ...

What Is Bone Cancer (Sarcoma)? What Causes Bone Cancer?  -  ‎Nov 19, 2009‎
Medical News TodayA small number of risk factors for the condition have been identified: Having a previous history of retinoblastoma. It is a rare type of childhood cancer ...

Keeping up appearances  -  ‎Nov 13, 2009‎
Malaysia StarSara Fikri, 29, a teacher at a school for special children, lost one eye to retinoblastoma cancer, a rapidly growing tumour on the retina. ...

Red Reflex Eye Test Recommended for Newborns  -  ‎Nov 7, 2009‎
eMaxHealth...glaucoma, retinoblastoma, retinal abnormalities, systemic diseases with ocular manifestations, and high refractive errors.? The statement went on to say ...

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and ...  -  ‎Nov 10, 2009‎
7thSpace Interactive (press release)...associated with a rapid decline in cyclin D1 protein levels and a reduction in the levels of both phosphorylated and total retinoblastoma protein (RB). ...

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits ...  -  ‎Oct 29, 2009‎
7thSpace Interactive (press release)PD 0332991 is an orally active, highly selective inhibitor of the cyclin D kinase (CDK)4 and CDK6 kinases with ability to block retinoblastoma (Rb) ...

Bristol to get Christmas lights 'to remember'  -  ‎Nov 6, 2009‎
Bristol Evening PostThe Mall will have a Giving Tree once again, this year supporting the Childhood Eye Cancer Trust, a UK-wide charity for people affected by retinoblastoma. ...

IDAHO LIONS IMPACT NEONATAL AND PEDIATRIC SCREENING  -  ‎Oct 28, 2009‎
Idaho State JournalThe Ret Cam will help prevent blindness in premature babies, diagnose retinoblastoma cancers in children, and to assist in the diagnosis of shaken baby ...

Nuova influenza/ Napoli, morti tre pazienti con patologie gravi  -  ‎Nov 19, 2009‎
APCOMEnrica Scarpato, 29 anni, aveva un retinoblastoma all'occhio sinistro e deficit psico-intellettivo. Entrambi sono morti per insufficienza respiratoria acuta ...

Erogazioni Fondazione Mps: la Ricerca scientifica e tecnologica  -  ‎Nov 18, 2009‎
SienaFree.itL'Associazione Genitori Italiana Retinoblastoma Onlus di Siena ha ricevuto un contributo pari a 15 mila euro per la somministrazione di farmaci ...

Nel Cortile del Podestà a Siena una maratona musicale a favore della ricerca ...  -  ‎Nov 13, 2009‎
SienaFree.itUna maratona musicale in favore dell'Associazione italiana per la ricerca sul retinoblastoma (Airr). E' quella che si svolgerà sabato 14 novembre, ...

Il punto regione per regione  -  ‎Nov 19, 2009‎
ANSAEra già affetta da retinoblastoma all'occhio sinistro e deficit psico-intellettivo. Pasquale Iovine, di 52 anni, era un disabile. Già affetto da epatopatia ...

«No me consta que haya profesionales que duden de la eficacia de la vacuna»  -  ‎Nov 14, 2009‎
La Voz de GaliciaA los 9 meses le detectaron un Retinoblastoma. El especialista que la está tratando me comenta que no le pongamos la vacuna y en cambio la pediatra nos dice ...

Rung giật nhãn cầu bẩm sinh của trẻ sơ sinh  -  ‎Nov 13, 2009‎
VOA Tiếng ViệtU bướu võng mạc (retinoblastoma): trẻ em mới sinh đ?u được bác sĩ nhi khoa r?i đèn [ophthalmoscope] vào mắt để xem có đốm đ? bình thư?ng (normal red reflex) ...

Teste em bebês evita doenças oculares  -  ‎Nov 14, 2009‎
A Tarde On Line...de doenças oculares, como a catarata, o glaucoma eo retinoblastoma (tumor que leva à morte), além de infecções, traumas de parto e até mesmo a cegueira. ...

Victoria Castel: ´La edad donde el cáncer se ceba más con los niños es entre ...  -  ‎Nov 9, 2009‎
LevanteNo, vemos niños recién nacidos hasta de 14 años, aunque hay determinados tumores que se dan en unas edades determinadas como el retinoblastoma que afecta ...

Fondazione Mps: Tutte le erogazioni a valere sul bando 2009  -  ‎Nov 17, 2009‎
SienaFree.it...genitori italiana retinoblastoma onlus (siena) - somministrazione di farmaci chemioterapici nel retinoblastoma - 15000, Ass.ne giovani insieme per. ...

Influenza A, tre vittime a Napoli. Oms: "Vaccino sicuro come quello stagionale"  -  ‎Nov 19, 2009‎
Adnkronos/IGNEnrica Scarpato, 29 anni è morta per insufficienza respiratoria acuta con broncopolmonite bilaterale da influenza H1N1, già colpita da retinoblastoma ...

Influenza A, Fazio: «Bisogna vaccinarsi per evitare che il virus si trasformi»  -  ‎Nov 19, 2009‎
Il MessaggeroEra già affetta da retinoblastoma all'occhio sinistro e deficit psico-intellettivo. Pasquale Iovine, di 52 anni, era un disabile. Già affetto da epatopatia ...

<i>«Sólo la buena atención pediátrica permite un diagnóstico precoz»</i>  -  ‎Oct 30, 2009‎
Las ProvinciasSon típicos del niño los tumores llamados embrionarios, neuroblastoma, meduloblastoma, nefroblastoma, retinoblastoma... que muy rara vez o nunca se ven en ...



Background information on Retinoblastoma [When available]

Retinoblastoma is a cancer of the retina. It is caused by a mutation in the Rb-1 protein. It occurs mostly in younger children and accounts for about 3% of the cancers occurring in children younger than 15 years. The estimated annual incidence is approximately 4 per million children.

The tumor may begin in one or both eyes. Retinoblastoma is usually confined to the eye but can spread to the brain via the optic nerve.

Retinoblastoma may be hereditary (inherited) or nonhereditary. The hereditary form may be in one or both eyes, and generally affects younger children. Retinoblastoma occurring in only one eye is often not hereditary and is more prevalent in older children. When the disease occurs in both eyes, it is always hereditary. Because of the hereditary factor, patients and their brothers and sisters should have periodic examinations, including genetic counseling, to determine their risk for developing the disease.

A statistical study by Dr Alfred G. Knudson in 1971 led to a hypothesis (later known as the Knudson hypothesis) about why some retinablastomas are hereditary and others occur by chance. This hypothesis led to the first identification of a tumor suppressor gene by a team led by Dr Thaddeus P. Dryja in 1986. Knudson won the 1998 Albert Lasker Medical Research Award for this work.

Hereditary retinoblastoma is caused by an inherited mutation in a single copy of the Rb1 gene. The remaining functional copy prevents most retinal cells from becoming cancer. However, one or more cells in the retina are likely to undergo a spontaneous loss of this functional copy, causing those cells to transform into cancer. This loss of the second copy of Rb1 is termed loss of heterozygosity, a frequent event in cancer for which retinoblastoma is the canonical example.

The patient's choice of treatment depend on the extent of the disease within and beyond the eye. Smaller tumors can be removed with laser surgery, thermo-, or cryotherapy.

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