Polycythemia vera

This page contains recent news articles, when available, and an overview of Polycythemia vera but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Polycythemia vera

YM BIOSCIENCES REPORTS FIRST PATIENT IN PHASE I/II TRIAL OF JAK1/JAK2 ...  -  23 Nov 2009
PR Newswire (press release)...a mutated form of which has been implicated in a variety of MPNs including myelofibrosis, polycythemia vera and essential thrombocythemia. ...

Polycythemia vera as a presentation of renal angiomyolipoma: a case report  -  ‎Oct 31, 2009‎
7thSpace Interactive (press release)This report describes a rare case of a woman diagnosed with renal angiomyolipoma and polycythemia vera. The report discusses the differential diagnosis ...

Life Central | Polycythemia.  -  ‎Nov 16, 2009‎
PR-inside.com (press release)Polycythemia vera is the disorder in which there is an overproduction of red blood cells, white blood cells and platelets. Secondary polycythemia ...

Blood Cancer Meeting Abstracts Released: BioBuzz  -  ‎Nov 10, 2009‎
TheStreet.com...s(INCY Quote) INCB018424 in patients with Advanced Polycythemia Vera (PV) and Essential Thrombocythemia (ET) Refractory to Hydroxyurea is being called ...

Incyte Beats Estimates Marginally  -  ‎Nov 9, 2009‎
Zacks.comThe oral formulation of the compound is undergoing phase III trials for the treatment of myelofibrosis, Polycythemia Vera and Essential Thrombocythemia. ...

Incyte Reports Third Quarter 2009 Financial Results and Provides Update on ...  -  ‎Nov 5, 2009‎
ReutersPolycythemia Vera and Essential Thrombocythemia * Continued patient enrollment of the Phase III registration trials, COMFORT-I and COMFORT- II. ...

Social activist Yonni Chapman dies  -  ‎Oct 29, 2009‎
Durham Herald SunHe battled Polycythemia Vera, a myeloproliferative disorder, which is a blood cancer in the leukemia family, for 29 years. “We all feel lucky to have had ...

Forschen in Amerika  -  ‎Nov 18, 2009‎
Bohmann...a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera". Peter Winzer von Bell Labs, Crawford Hill Labs, ...

Österreichische Ehrungen für Nachwuchswissenschafter in Nordamerika  -  ‎Nov 12, 2009‎
APA OTS (Pressemitteilung)...a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera" (erschienen im Journal: Cancer Cell 13, 1-10, ...

Ruptured artery possible cause of stroke  -  07 Aug 2009
SunJournal.comDONOHUE: My nephew, 49, had some tests and has been determined to have a blood disease called polycythemia vera. We are desperate to know if it is treatable

Status of cancer cluster investigations around the country  -  ‎Aug 1, 2009‎
Palm Beach PostImpact: Dozens have rare form of cancer called Polycythemia Vera, which causes excess red blood cell production. Cause: Under investigation.

New Drug For Children With High-risk Leukemia  -  ‎Jul 29, 2009‎
Science Daily (press release)According to Dr. Izraeli, a similar mutation of the JAK2 in Down syndrome and leukemia causes Polycythemia Vera, a disease common in adults that leads to

Incyte Corporation Q2 2009 Earnings Call Transcript  -  ‎Jul 30, 2009‎
Seeking AlphaCOMFORT-I is expected to enroll 240 patients with other primary myelofibrosis post-polycythemia vera MF or post-essential thrombocythemia MF using

West Virginia Redefines Dirty Energy as 'Alternative'  -  ‎Jul 14, 2009‎
SolveClimateIn fact, the specific genetic mutation involved in polycythemia vera has been linked to PAH exposure. And because radioactive elements are found in waste

Tracking a rare cancer  -  ‎Jul 27, 2009‎
Wilkes Barre Times-LeaderBetween 2001 and 2005, 97 cases of the rare blood disease polycythemia vera were reported to the state cancer registry in Luzerne, Schuylkill and Carbon

Drug Alternative Childhood Leukemia Chemo Developed  -  ‎Aug 2, 2009‎
MedIndiaAccording to Izraeli, a similar mutation of the JAK2 in Down syndrome and leukemia causes Polycythemia Vera, a disease common in adults that leads to the

Drexel professor investigates rare blood cancer  -  ‎Jul 31, 2009‎
Drexel University The Triangle OnlinePolycythemia Vera, which is diagnosed in 1 in 100000 people annually, is classified as a cancer because stem cells in the bone marrow do not respond to the

Morning Movers 7/21: JDAS, PKG, INCY, LAB, LXRX, CGEN Higher; RF ...  -  ‎Jul 21, 2009‎
StreetInsider.com (subscription)INCB18424, in patients with primary myelofibrosis, post-polycythemia vera myelofibrosis or post-essential thrombocythemia myelofibrosis.

xtremepicks.com: www.Xtremepicks.Com: Xtremepicks Alerts For ...  -  ‎Jul 22, 2009‎
Trading Markets (press release)...in patients with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET-MF).

BiomedReports: News and FDA Updates for Thermo Fisher (NYSE:TMO ...  -  ‎Jul 22, 2009‎
Trading Markets (press release)...in patients with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET-MF).

Incyte Reaches Agreement with FDA on a Special Protocol Assessment  -  ‎Jul 25, 2009‎
Trading Markets (press release)...in patients with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET-MF).

Incyte Reaches Agreement with FDA on a Special Protocol Assessment ...  -  ‎Jul 21, 2009‎
FOXBusinessMyelofibrosis is part of a related group of hematological neoplasms called myeloproliferative disorders that includes myelofibrosis, polycythemia vera and

Incyte (INCY) Reports In-Line Q2 Loss of $0.41; Provides Update on ...  -  ‎Jul 30, 2009‎
StreetInsider.com (subscription)240 patients with primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (PPV-MF) and post essential thrombocythemia myelofibrosis (PET-MF).

Signaling Pathway May Be CML Therapy Target  -  Dec 26, 2008
MedPage Today,26 -- New therapeutic approaches to two myeloproliferative disorders, chronic myeloid leukemia and polycythemia vera, may emerg,e from a series of cellular

Inhibition of the Bcl-x L Deamidation Pathway in ...  -  Dec 24, 2008
New England Journal of Medicine (subscription),Results The Bcl-x L deamidation pathway was inhibited in myeloid cells, but not T cells, in patients with CML or polycythemia vera.

Research and Markets: A Competitor Analysis for Janus Kinase (JAK ...  -  Dec 10, 2008
MarketWatchThe most advanced JAK2 inhibitors are also being evaluated in phase II trials for myelofibrosis, polycythemia vera and essential thrombocythemia.

Novel Pathway Involved In Therapy-resistant Cancers Discovered  -  Dec 24, 2008
Science Daily (press release)...the University of Cambridge and Addenbrooke’s Hospital, using cells from patients with chronic myeloid leukaemia (CML), and polycythemia vera (PV),

Exelixis Reports Phase 1 Data for XL019 at ASH Annual Meeting  -  Dec 7, 2008
WELT ONLINE,Mutational activation of JAK2 is observed in the majority of patients with myeloproliferative diseases including polycythemia vera,

Exelixis Reveals New Phase I Data Of XL019 Demonstrating Evidence ...  -  Dec 7, 2008
RTT News,Myeloproliferative disorders, which result in an overproduction of blood cells, include polycythemia vera, essential thrombocytosis, primary or idiopathic

Pathway Inhibited in Myeloproliferative Disorders Defect seen in ...  -  Dec 25, 2008
Modern Medicine,UK, and colleagues analyzed primary cells from patients with chronic myeloid leukemia or polycythemia vera for abnormalities of the proapoptotic Bcl-x L

Incyte's Selective JAK1 / 2 Inhibitor, INCB18424, Demonstrates ...  -  Dec 6, 2008
WELT ONLINE,The three main MPDs are polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF). Approximately 10 to 20% of patients with PV and ET

Health care for all: How to get involved  -  Dec 2, 2008
Kansas City Star,I traveled to Johns Hopkins in Baltimore and Cornell University Medical Center in New York City to meet with experts on my disease, polycythemia vera (PV).

Experimental Drug Fights Bone Marrow Cancers  -  Dec 9, 2008
Washington Post,There are no US Food and Drug Administration-approved targeted treatments for the "big three" MPDs -- polycythemia vera, essential thrombocythemia and

Promising New Drug Blocks Mutation In Bone Marrow Cancers  -  Dec 9, 2008
Science Daily (press release)The "big three" MPDs include polycythemia vera, essential thrombocythemia and primary myelofibrosis. Until now there have been no FDA-approved targeted

Incyte To Present Updated Results From Ongoing Phase II Trial of ...  -  Dec 6, 2008
RTT News,Study INCB18424-251 is an ongoing Phase II trial in patients with primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential

Energy Watch: Public health authorities consider link between coal ...  -  Oct 30, 2008
Facing South,The red dots on the map at top show the location of officially confirmed cases of polycythemia vera in three eastern Pennsylvania counties studied.

Tamaqua residents take issue with ash  -  Oct 23, 2008
Republican & Herald,A Hometown resident, Joe Murphy, brought up health issues in the area, telling council that he attended a recent discussion on polycythemia vera,

Incyte's JAK Inhibitor Demonstrates Rapid and Marked Clinical ...  -  Oct 26, 2008
Earthtimes (press release),...(as a topical treatment), myelofibrosis, polycythemia vera, essential thrombocythemia, multiple myeloma, and hormone refractory prostate cancer.

Incyte Reports Progress in Multiple Clinical Programs Announces ...  -  Nov 6, 2008
Genetic Engineering News (press release),INCB18424: Additional Myeloproliferative Diseases: Polycythemia Vera (PV) and Essential Thrombocythemia (ET) -- Ongoing enrollment and site initiation of an

Les mutations de JAK2 dans les syndromes myéloprolifératifs en 2008  -  Nov 12, 2008
Hématologie,Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia,

Its mysterious power may be a clue to a new theory about brains ...  -  Jun 23, 2008
New Yorker,...and although no one knows the mechanism, it’sa symptom of polycythemia vera, a rare condition in which the body produces too many red blood cells.

Hydroxyurea in children with sickle cell disease: When, how should ...  -  Jul 1, 2008
AAP News (subscription)It has been used for several decades in adults for the treatment of leukemia, polycythemia vera and myelodysplastic disease. In 1988, Platt, et al reported

Incyte's JAK Inhibitor Demonstrates Marked Clinical Benefits in ...  -  Jun 13, 2008
Centre Daily Times,...psoriasis (as a topical treatment), myelofibrosis, polycythemia vera essential thrombocythemia, multiple myeloma, and hormone refractory prostate cancer

A Review of Articles From Last Month's Archives of Pathology ...  -  May 15, 2008
RedOrbit,...in almost all cases of polycythemia vera and in about 50% of cases of essential thrombocythemia and chronic idiopathic myelofibrosis d. pancytopenic

S*BIO receives orphan drug designation for  -  May 15, 2008
Checkbiotech.org (press release),MPD is characterised by an excess of blood cells and the three main disorders include polycythemia vera (excess red blood cell mass),

CDC Ignores Scientific Evidence in Public Health Cases  -  May 5, 2008
Natural News.com,A study was conducted to analyze the high rates of a very rare form of blood cancer called Polycythemia Vera (PV). The agency released an abstract in

Family man loved outdoors, NASCAR  -  Mar 23, 2008
Idaho Press-Tribune,Forced into early retirement by polycythemia vera, which robbed him of his strength as his blood volume increased abnormally, Farmer still “made the best of

New Genetic Test Detects Rare, Deadly, Difficult-to-Diagnose Blood ...  -  Mar 7, 2008
PR Web (press release),Plainview, NY (PRWEB) March 7, 2008 -- Polycythemia vera may be a rare disorder - it affects just five of every 1 million adults in the US - but it makes up

Flow Cytometry and Molecular Genetics for Hematologic Neoplasms  -  Mar 21, 2008
Medscape (subscription)The detection of JAK2 mutation by this technique is very important for the diagnosis of polycythemia vera, chronic idiopathic myelofibrosis, and essential

Carwash operator/supplier dies  -  Feb 26, 2008
Carwash Online,...vice president of Quality Systems and Services Inc.,a carwash distributor and service company, died last week from complications from polycythemia vera,

Cytopia Nominates JAK2 Clinical Candidate for Myeloproliferative ...  -  Mar 17, 2008
Earthtimes,Myeloproliferative disorders are a group of diseases including myelofibrosis, polycythemia vera (PV) and essential thrombocythemia (ET) that affect over

Hepatitis C May Reduce EPO Requirements  -  Mar 15, 2008
Renal and Urology News,...not need EPO or have very low requirements usually prompts investigation for acquired renal cystic disease, renal cell carcinoma, or polycythemia vera.

PROFNET EXPERT ALERTS: Health & Medicine  -  Mar 6, 2008
StreetInsider.com (subscription),SHASHI PAWAR, Ph.D., DABMG, the director of genetics at ACUPATH LABORATORIES in New York: "Polycythemia vera may be a rare disorder, affecting just five of

Upbeat outlook on life  -  Feb 29, 2008
Journal Times,There are three basic disorders — polycythemia vera, essential thrombocytosis (also called essential thrombocythemia) and primary myelofibrosis.



Background information on Polycythemia vera [When available]

Primary polycythemia, often called polycythemia vera (PCV), polycythemia rubra vera (PRV), erythremia, or just PV, occurs when excess erythrocytes are produced as a result of a proliferative abnormality of the bone marrow. Often, excess white blood cells (leukocytosis) and platelets (thrombocytosis) are also produced. It is, therefore, classified as a myeloproliferative disease.

In primary polycythemia there may be 8 to 9 million and occasionally 11 million erythrocytes per cubic millimeter of blood, and the hematocrit may be as high as 70 to 80%. In addition, the total blood volume sometimes increases to as much as twice normal. The entire vascular system can become markedly engorged with blood, and circulation times for blood throughout the body can increase up to twice the normal value. The increased numbers of erythrocytes can increase the viscosity of the blood to as much as five times normal. Capillaries can become plugged by the very viscous blood, and the flow of blood through the vessels tends to be extremely sluggish.

As a consequence of the above, people with untreated PV are at a risk of various thrombotic events (deep venous thrombosis, pulmonary embolism), heart attack and stroke, and have a substantial risk of Budd-Chiari syndrome (hepatic vein thrombosis). The condition is considered chronic; no cure exists. Symptomatic treatment (see below) can normalize the blood count and most patients can live a normal life for years.

Search the web for more resources on Polycythemia vera



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