Peripheral Blood Stem Cell Transplantation

This page contains recent news articles, when available, and an overview of Peripheral Blood Stem Cell Transplantation but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Peripheral Blood Stem Cell Transplantation

Leukemia survivor is advocate for bone marrow registries  -  ‎Jul 27, 2009‎
The Wichita EagleThe cells also might be collected directly from blood in a process known as "peripheral blood stem cell transplantation," said oncologist Bassam Mattar,

New Study Shows PCR and FCR Have Significant Activity in B-cell ...  -  Dec 8, 2008
MarketWatch...have undergone high-dose melphalan therapy followed by autologous peripheral blood stem cell transplantation and failed to achieve a complete response.

Pakistan Institute of Medical Sciences may have stem cell and bone ...  -  Jul 2, 2008
Pakistan Daily,...“Bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) are procedures that restore stem cells that have been destroyed by

Flow Cytometry as a diagnostic tool  -  Jun 23, 2008
Express Pharma,These stem cells are used in bone marrow and peripheral blood stem cell transplantation. The distributed nature of the hematopoietic system makes it



Background information on Peripheral Blood Stem Cell Transplantation [When available]

Bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) are procedures that restore stem cells that have been destroyed by high doses of chemotherapy and/or radiation therapy. There are three types of transplants:
  • In autologous transplants, patients receive their own stem cells.
  • In syngeneic transplants, patients receive stem cells from their identical twin.
  • In allogeneic transplants, patients receive stem cells from their brother, sister, or parent. A person who is not related to the patient (an unrelated donor) also may be used.
Why are BMT and PBSCT used in cancer treatment?

One reason BMT and PBSCT are used in cancer treatment is to make it possible for patients to receive very high doses of chemotherapy and/or radiation therapy. To understand more about why BMT and PBSCT are used, it is helpful to understand how chemotherapy and radiation therapy work.

Chemotherapy and radiation therapy generally affect cells that divide rapidly. They are used to treat cancer because cancer cells divide more often than most healthy cells. However, because bone marrow cells also divide frequently, high-dose treatments can severely damage or destroy the patient’s bone marrow. Without healthy bone marrow, the patient is no longer able to make the blood cells needed to carry oxygen, fight infection, and prevent bleeding. BMT and PBSCT replace stem cells that were destroyed by treatment. The healthy, transplanted stem cells can restore the bone marrow’s ability to produce the blood cells the patient needs.

In some types of leukemia, the graft-versus-tumor (GVT) effect that occurs after allogeneic BMT and PBSCT is crucial to the effectiveness of the treatment. GVT occurs when white blood cells from the donor (the graft) identify the cancer cells that remain in the patient’s body after the chemotherapy and/or radiation therapy (the tumor) as foreign and attack them. More from the National Cancer Institute

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