Paraganglioma

This page contains recent news articles, when available, and an overview of Paraganglioma but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Paraganglioma

Composite paraganglioma-ganglioneuroma in the retroperitoneum  -  ‎Nov 4, 2009‎
7thSpace Interactive (press release)Composite paraganglioma-ganglioneuroma of the retroperitoneum is very rare.Case presentationWe present an unusual case of retroperitoneal composite ...

Poland Haunted Barn benefitting residents  -  ‎Oct 28, 2009‎
Brazil TimesWhittaker was diagnosed with a rare disease called Paraganglioma, which forms multiple benign tumors on the upper torso and can cause damage to the ...

Parasympathetic Paragangliomas Are Part of the Von Hippel-Lindau Syndrome  -  ‎Nov 4, 2009‎
Journal of Clinical Endocrinology and MetabolismResults: Apart from germline VHL mutations, no additional mutations were found in the paraganglioma-related tumor suppressor genes SDHB, SDHC, and SDHD. ...

Un estudio en hongos desvela un gen asociado a un cáncer humano  -  07 Aug 2009
ADN.esTambién descubrieron que un grupo de pacientes humanos con paraganglioma hereditario, un raro tumor neuroendocrino, portaban mutaciones que inactivaban los

?现全新抑癌基因  -  07 Aug 2009
科学时报...?现一个全新的抑癌基因SDH5,相关文章SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma?表在《科学》在线版。

APPROACH TO THE PATIENT The Approach to the Patient with Paraganglioma  -  ‎Aug 5, 2009‎
Journal of Clinical Endocrinology and MetabolismUp to one third of all symptomatic presentations of pheochromocytoma or paraganglioma are due to germline mutations in one of six genes defining multiple

The Succinate Dehydrogenase Genetic Testing in a Large Prospective ...  -  ‎Aug 5, 2009‎
Journal of Clinical Endocrinology and MetabolismContext: Germline mutations in SDHx genes cause hereditary paraganglioma. Objective: The aim of the study was to assess the indications for succinate

A New Discovery In Genetic Mutation  -  ‎Jul 29, 2009‎
OneindiaScientists from University of Utah have identified a genetic mutation linked to hereditary form of a rare neuroendocrine tumour called paraganglioma (PGL).

80?中国?士《Science》?现全新抑癌基因  -  ‎Aug 3, 2009‎
生物通Germline loss-of-function mutations in the human SDH5 gene, located on chromosome 11q13.1, segregate with disease in a family with hereditary paraganglioma

Impact of Screening Kindreds for SDHD p.Cys11X as a Common ...  -  Dec 4, 2008
Journal of Clinical Endocrinology and Metabolism,Context and Objective: Germline mutations of the genes SDHB, SDHC, and SDHD predispose to paraganglioma syndromes. Mutation-specific counseling

About the Cover  -  Dec 4, 2008
Journal of Clinical Endocrinology and Metabolism,Tyrosine hydroxylase immunohistochemistry in a catecholamine producing abdominal paraganglioma (left panel), a biochemically silent abdominal paraganglioma

Questions in Daily Urologic Practice  -  Dec 9, 2008
Journal of American Medical Association (subscription),Part 5 details the salient gross and microscopic features of benign and malignant adrenal tumors, especially pheochromocytoma and paraganglioma.

PHD2 Mutation and Congenital Erythrocytosis with Paraganglioma  -  Dec 17, 2008
New England Journal of Medicine (subscription),We describe a patient with erythrocytosis and recurrent paraganglioma who carries a newly discovered PHD2 mutation. This mutation affects PHD2 function and

Errant inmate's time increased to 20 years  -  Oct 28, 2008
Marshall County Tribune,An Indiana doctor said he was treated for paraganglioma nearly three years ago. A review of Internet sites indicates that paraganglioma usually includes

Molecular Insight Pharmaceuticals, Inc. To Present Interim Phase 1 ...  -  May 16, 2008
Business Wire (press release),...with malignant pheochromocytoma/paraganglioma. The trial is part of the company’s program to develop Azedra for the treatment of neuroendocrine cancers.

Molecular Insight Pharmaceuticals, Inc. to Present Data on Four ...  -  May 20, 2008
PR-Inside.com (Pressemitteilung),...safety and efficacy of Iobenguane I 131 in malignant pheochromocytoma and paraganglioma (Pheo) Authors: R. Coleman(1), MA Morse(1), N. LaFrance(2),

widower loses out in tv love quest  -  Nov 15, 2007
Oxford Mail,...and she chose to meet the other man instead. mr morris's wife michele died in 2000, aged 42, from the rare cancer paraganglioma, leaving him to care for

The Effects of Carbidopa on Uptake of 6- 18 F-Fluoro-L-DOPA in PET ...  -  Oct 1, 2007
Journal of Nuclear Medicine (subscription)The aim of this study was to investigate the sensitivity of 18 F-DOPA PET in the detection of paraganglioma and its metastatic lesions and to evaluate



Background information on Paraganglioma [When available]

A paraganglioma is a rare neoplasm that can be found in the head and neck region and other less common areas. They are usually considered benign and complete surgical removal results in cure. However, in about 3% of cases they are malignant and have the ability to metastasize. Paragangliomas are still sometimes called glomus tumors (not to be confused with glomus tumors of the skin) and chemodectomas, but paraganglioma is the currently accepted and preferred term.

Paragangliomas arise from the glomus cells, which are special chemoreceptors located along blood vessels that have a role in regulating blood pressure and blood flow. The main concentration of glomus cells are found are in the carotid body, located in the upper neck at the branching of the common carotid artery, and the aortic bodies, located near the aortic arch. The glomus cells are a part of the paraganglion system composed of the extra-adrenal paraganglia of the autonomic nervous system, derived from the embryonic neural crest. Thus, paragangliomas are a type of neuroendocrine tumor, and are closely related to pheochromocytomas. Although all paragangliomas contain neurosecretory granules, only about 1-3% have clinical evidence of oversecretion.

Paragangliomas are found predominantly in the abdomen (85%) and the thorax (12%), and only 3% are found in the head and neck region. Most occur as single tumors. When they occur in multiple sites they are usually found as a part of a heritable syndrome such as multiple endocrine neoplasia types II-A and II-B and Carney's complex.

Familial paragangliomas are found in 10-50% of cases, are often multiple and bilateral, and occur at an earlier age. The genes SDHD (previously known as PGL1), PGL2, and SDHC (previously PGL3) have been identified as the genes which can cause familial paragangliomas when mutated.

According to the World Health Organization classification of neuroendocrine tumors, paragangliomas are classified as having a neural cell line of origin. In the categorization proposed by Wick, the paragangliomas belong to Group II

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