Metastases

This page contains recent news articles, when available, and an overview of Metastases but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Metastases

Sirtex Announces Creation of Centers of Excellence Program and Inaugural Honorees  -  23 Nov 2009
Earthtimes (press release)Manufactured by Sirtex, SIR-Spheres microspheres are the only FDA-approved radioactive microsphere therapy for the treatment of colorectal liver metastases. ...

Amgen Recognized for Best Pipeline and Best New Drug at Scrip Awards  -  23 Nov 2009
PR Newswire (press release)...prostate cancer patients), as well as for its potential to delay bone metastases and inhibit and treat bone destruction across many stages of cancer. ...

Interim Phase 2 Survival Data for PV-10 Shows Markedly Longer Overall and ...  -  23 Nov 2009
Earthtimes (press release)...the first evidence of regression of visceral metastases in two of five subjects in this group who had documented visceral metastases at enrollment. ...

Initial Phase 2 Results for Myriad Pharmaceuticals' Azixa(TM) (MPC-6827) in ...  -  ‎Nov 18, 2009‎
CNNMoney.com (press release)The brain is a preferential site for melanoma metastases; 40-60% have confirmed brain lesions. In one study of 702 melanoma patients known to have ...

ASTRO: Brain Irradiation Cuts Lung CA Metastases  -  ‎Nov 3, 2009‎
MedPage TodayExplain to patients that in this study prophylactic brain irradiation prevented metastases from lung cancer but did not improve survival. ...

Unexplained liver haemorrhage after metastasis radiofrequency ablation  -  ‎Nov 21, 2009‎
Science CentricApproximately one in four of these patients have metastases at diagnosis, liver being the most common site involved. Although historically it was considered ...

Incidence of brain metastases in renal cell carcinoma treated with sorafenib ...  -  ‎Nov 12, 2009‎
UroTodayThis retrospective study evaluated the incidence of brain metastases in a subgroup of patients with metastatic renal cell carcinoma (RCC) who were randomly ...

The First Framework on Brain Metastases Therapy Will Soon Be Released  -  ‎Nov 7, 2009‎
TopCancerNews.comThe brain metastases affect approximately 500000 people each year in the United States. A team of investigators set up to find a proper framework for ...

Diagnostic role of whole body bone scintigraphy in atypical skeletal ...  -  ‎Nov 20, 2009‎
7thSpace Interactive (press release)A case of atypical skeletal tuberculosis mimicking multiple secondary metastases on radiologic and scintigraphic imaging is presented to emphasize the ...

WHAT'S UP DOC? Be aware of lung cancer risks  -  ‎Nov 17, 2009‎
Daily News TribuneStage I lung cancer has not metastasized to the lymph nodes or to other locations in the body (distant metastases), but is localized to the affected lung. ...

Bureaucrats Making Medical Decisions  -  ‎Nov 17, 2009‎
Wall Street JournalWill toxicity outrace cancer metastases? Why will a remote bureaucrat make this decision rather than the patient's physician and the patient?

Four Immunocytochemical Markers Better Distinguish Liver Cancer From Liver ...  -  ‎Nov 10, 2009‎
DG NewsCHICAGO -- November 10, 2009 -- Because it can be very difficult to distinguish liver metastases of adenocarcinoma from cancer cells which ...

Tulane Cancer Center to begin novel clinical trial for late-stage prostate ...  -  ‎Nov 17, 2009‎
Genetic Engineering News (press release)Patients most often die as a consequence of the metastases not the primary cancer so preventing cancer from spreading and controlling cancer that has spread ...

Threshold Pharmaceuticals Presents Interim Prostate Cancer Data From Early ...  -  ‎Nov 18, 2009‎
CNNMoney.com (press release)All 8 patients had bone metastases and 5 of the 8 patients also had lymph node metastases. TH-302 was administered on days 1, 8 and 15 of a four week cycle. ...

Nanoparticles Detect and Purge Metastases in Lymph Nodes  -  ‎Oct 30, 2009‎
Nanotechwire.comDr. Zharov and his colleagues next showed that they could use photoacoustic techniques to detect both melanoma and breast cancer metastases in sentinel ...

Late cutaneous metastases to the face from malignant pleural mesothelioma: A ...  -  ‎Nov 9, 2009‎
7thSpace Interactive (press release)During its relative short course, this malignant neoplasm can give local and, rarely, distant haematogenous metastases in different organs. ...

ASCO calls for more research into radiofrequency ablation of hepatic ...  -  ‎Nov 5, 2009‎
HemOncTodayThe panel suggested eight such trials, including a comparison between hepatic resection vs. radiofrequency ablation for resectable colorectal metastases or ...

Aiming To Avoid Damage To Neurocognitive Areas Of The Brain During Cranial ...  -  ‎Nov 3, 2009‎
Science Daily (press release)It is also used prophylactically to prevent the development of overt intracranial metastases in patients diagnosed with small-cell lung carcinoma. ...

Nexavar® May Reduce Brain Metastases in Patients with Metastatic Renal Cell ...  -  ‎Oct 28, 2009‎
Cancer ConsultantsResearchers from France and Poland have reported that Nexavar® (sorafenib) may reduce the incidence of brain metastases in patients with metastatic renal ...

Prima Biomed in trading halt  -  ‎Nov 16, 2009‎
Australian Life ScientistPrima Biomed's flagship product is CVac, which is administered post-surgery and post-chemotherapy to delay the relapse and control the metastases of ovarian ...

PET-CT vs. whole-body MRI  -  ‎Nov 13, 2009‎
European Hospital...'To detect lymph node and organ metastases in the entire body most cancers require a whole-body scan. Over the past few years MRI developed into a modality ...

German Research Foundation approves 9.4 million euros funding for University ...  -  ‎Nov 20, 2009‎
News-Medical.netUncontrolled cell motility is one of the key characteristics of malignant tumor cells and their subsequent spread through the formation of metastases. ...

Research Roundup: Team led by Henry Ford doctor develops brain cancer ...  -  ‎Nov 1, 2009‎
Crain's Detroit BusinessThe first national treatment guidelines for brain metastases, which account for nearly 500000 new cancers each year in the United States, ...

Intramedullary Spinal Cord Metastasis  -  ‎Nov 9, 2009‎
Archives of Neurology3 Despite the fact that 18-FDG-PET/CT is not suited to the detection of brain metastases owing to high glucose uptake in the normal brain, it is useful in ...

How MicroRNAs Suppress Tumor Metastasis  -  ‎Oct 28, 2009‎
Science Daily (press release)ScienceDaily (Oct. 28, 2009) — Metastases are responsible for over 90% of cancer deaths. In the upcoming issue of G&D, Dr. Robert Weinberg (MIT) and ...

Long-term Outcomes Data Validates the Utility of PROSTASCINT in Guiding ...  -  ‎Nov 4, 2009‎
ReutersBiochemical disease free survival (bDFS) was also evaluated based on risk group status and on the presence or absence of lymph node metastases found on the ...

OTC: Genta Announces Results of AGENDA Phase 3 Trial of Genasense(R) in ...  -  ‎Nov 16, 2009‎
RTT News (press release)...soft tissue, lymph nodes 25 24 Liver metastases 24 25 Other visceral metastases 51 52 Disease stage" (%) Distant metastases 95 97 Loco-regional 5 3 ...

Central abdominal uptake of indium-111 capromab pendetide (ProstaScint ...  -  ‎Nov 11, 2009‎
UroTodayCentral abdominal uptake (CAU) on immunoscintigraphy with capromab pendetide (CP) (ProstaScint) suggests the presence of metastases from prostate cancer, ...

Breaching a Barrier to Fight Brain Cancer  -  ‎Nov 16, 2009‎
New York TimesBut the technique might also be useful for brain metastases, meaning cancer that has spread from other parts of the body, like the breasts or lungs ...

Evaluation of 132 Nonthyroid Neck Mass Biopsies With Pathologic Analysis Over ...  -  ‎Nov 20, 2009‎
Journal of Ultrasound in Medicine (subscription)We found metastases in 31 biopsies (23.5%). Following these 2 were 29 lymph node biopsies. No major complications were noted. ...

Targeting the v β 3 Integrin for Small-Animal PET/CT of Osteolytic Bone Metastases  -  ‎Oct 29, 2009‎
Journal of Nuclear Medicine (subscription)Conclusion: Together, these data suggest that 64 Cu-RGD has the potential to effectively image osteolytic bone metastases and monitor the physiologic ...

Neoadjuvant VEGF-Targeted Therapy in Renal Cell Carcinoma  -  ‎Nov 19, 2009‎
Renal and Urology NewsA prospective trial of sunitinib in RCC patients with unresectable primary tumors (with or without distant metastases) is currently ongoing at Cleveland ...

BioMed News Bytes: AstraZeneca, Delcath, Unilife  -  ‎Nov 20, 2009‎
Seeking Alpha (blog)Enrollment in the Phase 2 clinical study of the Delcath PHP System with melphalan for patients with inoperable liver metastases from neuroendocrine tumors ...

YM BIOSCIENCES REPORTS FISCAL FIRST QUARTER 2010 OPERATIONAL AND FINANCIAL RESULTS  -  ‎Nov 11, 2009‎
Trading Markets (press release)YM initiated randomized, double-blind Phase II, trials in patients with brain metastases from non-small cell lung cancer (NSCLC) and in NSCLC patients ...

ImmunoGen, Inc. Announces Encouraging Clinical Data with Its IMGN901 Compound ...  -  ‎Nov 17, 2009‎
WELT ONLINEA third patient entered Study 002 with bone metastases and had previously been treated with three different combination regimens of chemotherapy. ...

Synta Presents Preclinical Data on Next Generation Hsp90 Inhibitor, STA-9090  -  ‎Nov 18, 2009‎
RTT News (press release)1 "Metastases taken from gastrointestinal stromal tumor patients whose cancers had progressed after treatment with imatinib are remarkably heterogeneous, ...

NovaRx Corporation Announces FDA Approval of Protocol Amendment to Special ...  -  ‎Nov 4, 2009‎
ReutersThe amendment will expand patient eligibility and enable study investigators to treat patients with stable brain metastases. As many as one in three NSCLC ...

Study resets the risk, benefits of preventive radiation  -  ‎Nov 12, 2009‎
Cancerfacts.comThe study found that patients with non-small cell lung cancer treated with PCI have a significantly decreased risk of developing brain metastases by 10 ...

Imaging Techniques May Help Predict Response to Head and Neck Cancer Treatment  -  ‎Nov 16, 2009‎
Science Daily (press release)..."In addition to early prediction of treatment response, PET-CT provides early detection of distant metastases, which permits earlier intervention in ...

Australia's premier life sciences news website  -  ‎Nov 1, 2009‎
Lifescience LabTo date, few methodologies are available to understand the molecular basis of metastases. With developments in RNAi, in particular, lentiviral-based ...

Algeta Results for the Third Quarter 2009  -  ‎Nov 12, 2009‎
Ad-Hoc-News (Pressemitteilung)15 - 34th ESMO Congress in September reinforces the potential of Alpharadin to become the first choice treatment for bone metastases in cancer patients. ...

Vessel Type Linked to Disease Severity in Prostate Cancer Study finds ...  -  ‎Oct 29, 2009‎
ModernMedicineDuring 20 years of follow-up, the researchers observed that 44 men died of cancer or developed bone metastases. After adjusting for various factors, ...

Elekta Presents New Image-Guidance Solutions at Capital Markets Day in Chicago ...  -  ‎Nov 2, 2009‎
ReutersElekta presented new independent clinical research discussing the advantages of stereotactic radiosurgery for treating of multiple brain metastases in ...

MannKind Corporation Q3 2009 Earnings Call Transcript  -  ‎Nov 2, 2009‎
Seeking Alpha (blog)Of the 18 patients treated, 4 had metastases confined to the lymphatic system. All four of these patients with lymphatic metastatic disease achieved durable ...

YM BIOSCIENCES REPORTS FISCAL FIRST QUARTER 2010 OPERATIONAL AND FINANCIAL RESULTS  -  ‎Nov 12, 2009‎
PR Newswire (press release)YM initiated randomized, double-blind Phase II, trials in patients with brain metastases from non-small cell lung cancer (NSCLC) and in NSCLC patients ...

Imaging Tests Help Determine Cancer Treatment Success  -  ‎Nov 18, 2009‎
Ivanhoe..."In addition to early prediction of treatment response, PET-CT provides early detection of distant metastases, which permits earlier intervention in ...

Delcath Systems Reports Substantial Progress  -  ‎Nov 19, 2009‎
PR Newswire (press release)Enrollment in the Phase II clinical study of the Delcath PHP System with melphalan for patients with inoperable liver metastases from neuroendocrine tumors ...

Cleveland Clinic, Johns Hopkins medical talks to go head to head  -  ‎Nov 20, 2009‎
Palm Beach Daily News..."In 2009, 91 percent had localized disease and only 4 percent presented with bony metastases. Thus today men have a choice that they never had before," said ...

PTEN expression and KRAS mutations in the prediction of benefit from cetuximab ...  -  ‎Nov 6, 2009‎
American Journal of Hemotology and OncologyMoreover, since a significant discrepancy between primary tumors and paired metastases was found with regard to the expression of EGFR, 16 pAKT, and MAPKs, ...

Predicting response of metastatic colorectal cancer to therapy using ...  -  ‎Nov 9, 2009‎
American Journal of Hemotology and OncologyNevertheless, the concordance of PTEN and phosphorylated AKT (pAKT) expression of primary tumors and related metastases was only 60% and 68%, respectively. ...



Background information on Metastases [When available]

Metastasis (Greek: change of the state) is the spread of cancer from its primary site to other places in the body. Localized spread to lymph nodes is not normally counted as metastasis, although this is a sign of poor prognosis.

Cancer cells can break away from a primary tumor, penetrate into lymphatic and blood vessels, circulate through the bloodstream, and grow in a distant focus (metastasize) in normal tissues elsewhere in the body.

Tumors are classified as either benign or malignant. Malignant tumors can spread by invasion and metastasis while benign tumors cannot (and only grow locally). By definition, the term "cancer" applies only to malignant tumors. Still, some tumors with benign histology can behave as malignant tumors, for example in brain tumors, where treatment has to be as aggressive as with malignant disease.

Patients diagnosed with cancer want to know whether their disease is local or has spread to other locations. It is the ability to spread to other tissues and organs that makes cancer a potentially life-threatening disease, so there is great interest in understanding what makes metastasis possible for a cancerous tumor.

Metastatic tumors are very common in late stage of the disease. The spread of metastases may occur via the blood or the lymphatics. Usually sarcomas spread by the hematogenous route, while carcinomas spread by the lymphatic route. The most common places for the metastases to occur are the adrenals, liver, brain and the bones. There is also a propensity for certain tumors to seed in particular organs. For example, prostate cancer usually metastasizes to the bones. Similarly, colon cancer has a tendency to metastasize to the liver. Stomach cancer often metastasizes to the ovary in women, where it forms the Krukenberg tumor.

When cancer cells spread to form a new tumor, it is called a secondary, or metastatic tumor, and its cells are like those in the original tumor. This means, for example, that if breast cancer spreads (metastasizes) to the lung, the secondary tumor is made up of abnormal breast cells (not abnormal lung cells). The disease in the lung is metastatic breast cancer (not lung cancer).

Cancer cells may spread to lymph nodes (regional lymph nodes) near the primary tumor. This is called nodal involvement, positive nodes, or regional disease. Cancer cells can also spread to other parts of the body, distant from the primary tumor. Doctors use the term metastatic disease or distant disease to describe cancer that spreads to other organs or to lymph nodes other than those near the primary tumor.

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