Li-Fraumeni Syndrome

This page contains recent news articles, when available, and an overview of Li-Fraumeni Syndrome but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Li-Fraumeni Syndrome

Breast Cancer Risk Is Not So Easy to Figure Out  -  23 Nov 2009
U.S. News & World Report...known genetic mutation—such as mutations in the BRCA1 and BRCA2 genes (as well as less common inherited problems like Li-Fraumeni syndrome)—or a history ...

What Is Bone Cancer (Sarcoma)? What Causes Bone Cancer?  -  ‎Nov 19, 2009‎
Medical News TodayHaving a rare genetic condition known as Li-Fraumeni syndrome. Having Paget's disease which is an uncommon bone condition that causes weakening of the bones ...

Family living with cancer timebomb  -  ‎Aug 3, 2009‎
Shields GazetteResearch into their deaths has revealed the family carry a faulty gene known as Li Fraumeni Syndrome (LFS), which often greatly increases the risk of cancer

New and attractive strategy for the development of anti-tumour drugs  -  Dec 14, 2008,Two well documented examples of this kind of congenital predisposition are pediatric adrenocortical carcinoma and Li-Fraumeni syndrome.

DNA: Too Much--or Too Little--Can Be a Bad Thing  -  Nov 14, 2008
Science Now,For example, take Li-Fraumeni syndrome, a genetic condition that leads to a number of cancers. In work published in August in the Proceedings of the

Cumulative incidence of subsequent malignant neoplasms after ...  -  Oct 27, 2008
MedscapeMultiple primary cancers in families with Li-Fraumeni syndrome. J Natl Cancer Inst. 1998;90:606-611. Abstract Alter BP. Cancer in Fanconi anemia, 1927-2001.

Ark floats gene therapy's boat, for now  -  Oct 24, 2008 (subscription),...(BLA) for Advexin (contusugene ladenovec), an orphan-designated adenoviral gene therapy for treating head and neck cancer and Li-Fraumeni syndrome.

Which breast imaging is best for you?  -  May 7, 2008
Cape Cod Times,You have Li-Fraumeni syndrome, Cowden syndrome or Bannayan-Riley-Ruvalcaba syndrome - or you may have one of these syndromes based on a history in a

Scans spot hidden tumors in rare cancer syndrome  -  26 Mar 2008
Medicexchange,...tumors in three of 15 patients with Li-Fraumeni syndrome (LFS), a rare genetic cancer syndrome for which no screening tests have been recommended.

PET/CT May Unmask Hidden Cancers in Li-Fraumeni Patients  -  Mar 20, 2008
MedPage Today,By Charles Bankhead, Staff Writer, MedPage Today BOSTON, March 20 -- Occult malignancies in patients with Li-Fraumeni syndrome have more difficulty hiding

F18-Fluorodeoxyglucose–Positron Emission Tomography/Computed ...  -  Mar 18, 2008
Journal of American Medical Association (subscription),MD, MPH Context Individuals with Li-Fraumeni syndrome (LFS) have an inherited cancer predisposition to a diverse array of malignancies beginning early

Full-Body Scans May Help the Highly Cancer-Prone  -  Mar 21, 2008
U.S. News & World Report,In most people with the condition, called Li-Fraumeni syndrome (LFS), a mutation in the TP53 tumor suppressor gene makes them highly susceptible to a

Scans spot hidden tumours  -  Mar 19, 2008
Times of India,For instance, a full-body PET/CT scanning detected unsuspected tumours in three out of 15 patients, with Li-Fraumeni syndrome (LFS), a rare genetic cancer

Animated Figure  -  Mar 18, 2008
Journal of American Medical Association (subscription),This animated figure supplement is an animated sequence of whole body maximum-intensity-projection (MIP) images of a patient with Li-Fraumeni Syndrome.

Study: PET scans may spot rare cancers  -  Mar 20, 2008
United Press International...scanning combined with computed tomography, or CT, scans detected unsuspected, treatable tumors in three of 15 patients with Li-Fraumeni syndrome -- a

Friends remember UW student Sarah Plants  -  Feb 26, 2008
Daily - University of Washington,7 of a brain tumor linked to Li-Fraumeni Syndrome, the same rare hereditary disorder that claimed the lives of her father and brother.

Genetics and Genomics for Clinicians  -  Mar 18, 2008
Journal of American Medical Association (subscription),In a preliminary report involving 15 asymptomatic members of families with Li-Fraumeni syndrome (which is associated with inherited predisposition to a wide

Orphan News :: Treatment & Health  -  Mar 18, 2008 (press release),The Company is also seeking approval for ADVEXIN in Europe for the treatment of the inherited cancer indication Li-Fraumeni Syndrome (LFS),

Full Text  -  Mar 6, 2008
Science Magazine (subscription)Further, heterozygous chk2 germline mutations predispose one to cancer and can occasionally be associated with a Li-Fraumeni syndrome that is

Introgen Plans to Expand Biomarker Database in Phase 3 Trials and ...  -  Dec 20, 2007
FOX NewsThe Company's MAA for ADVEXIN for the potential treatment of Li-Fraumeni Syndrome, a genetically inherited cancer, was accepted for filing by the European

Introgen to study extra data on head and neck cancer therapy  -  Dec 20, 2007
ReutersThe MAA for Advexin to treat Li-Fraumeni Syndrome -- a genetically inherited disease that increases the risk of developing multiple cancers -- had been

EMEA accepts Introgen Therapeutics' Advexin for review  -  Nov 28, 2007
Trading Markets (press release),The review will be based on clinical efficacy and safety results from the use of Advexin in Li-Fraumeni Syndrome and in a variety of non-inherited cancers

Market Report -- In Play (INGN)  -  Dec 20, 2007
MSN MoneyThe potential treatment of Li-Fraumeni Syndrome, a genetically inherited cancer, was accepted for filing by the European Medicines Agency last month.

Introgen CEO gets new contract  -  Dec 19, 2007
Austin American-Statesman,Administration for its Advexin cancer drug, and is seeking approval in Europe to market the drug to treat the inherited cancer Li-Fraumeni Syndrome.

Gendux Announces Acceptance of Its ADVEXIN Marketing Authorization ...  -  Nov 27, 2007
Business Wire (press release),...for technical review by the European medicines regulatory authority (the “EMEA?) for the treatment of an inherited cancer, Li-Fraumeni Syndrome (“LFS?).

Cancer-Suppressing Gene Tied to Female Fertility  -  Nov 28, 2007
Forbes,..."There are about 250 families in the United States that have defects in the p53 gene, a condition called Li-Fraumeni syndrome.

Compound activates anti-cancer gene to fight skin cancer  -  Dec 5, 2007,El-Deiry specifically highlights Li-Fraumeni syndrome - a rare hereditary condition in which sufferers possess a mutation in p53 gene that greatly increases

introgen and its gendux unit submit first marketing authorization ...  -  Nov 13, 2007
Trading Markets (press release),...a targeted p53 tumor suppressor therapy for the treatment of li-fraumeni syndrome cancers. advexin is a targeted molecular therapy with the potential to

rare cancer-causing syndrome found, for the first time, in singapore  -  Nov 5, 2007
Science Daily (press release)...a person should have two normal copies of the powerful p53 tumor suppressor gene. but in the disorder known as li-fraumeni syndrome (lfs), one defective

introgen, gendux submit marketing authorization application for ...  -  Nov 14, 2007
FDA news (subscription),...a treatment of li-fraumeni syndrome (lfs). lfs is a cancer syndrome characterized by the inheritance of an abnormal p53 tumor suppressor. without p53

introgen applies to market advexin in europe  -  Nov 13, 2007,...a tumor suppressor therapy for use in the treatment of a type of cancer known as li-fraumeni syndrome. austin-based introgen (nasdaq: ingn) has offices

austin firm seeks ok to sell drug in europe  -  Nov 13, 2007
Austin American-Statesman, that is furthest along in the approval process. it is a gene-based cancer drug designed to combat head and neck cancers and li-fraumeni syndrome,

introgen therapeutics reports third quarter 2007 financial and ...  -  Nov 9, 2007
Genetic Engineering News (press release),..."we are on track to achieve our major milestones of advexin registration submissions for two oncology indications, li-fraumeni syndrome cancers and

Introgen says cancer therapy works better for some  -  Sep 27, 2007
ReutersPeople with Li-Fraumeni Syndrome, a rare hereditary disorder that puts people at high risk of developing multiple cancers, are born with p53 mutations.

Introgen presents biomarker data demonstrating abnormal p53 ...  -  Sep 27, 2007
Reuters...abnormal p53 biomarker and tumor response after treatment with Advexin in patients with head and neck, lung, prostate and Li-Fraumeni Syndrome cancers.

American Cancer Society Recommends New Breast Cancer Screenings ...  -  Sep 27, 2007
Associated Content,Other factors include radiation to the chest between the ages of 10 and 30 or having Li-Fraumeni syndrome, Cowden syndrome, or Bannayan-Riley-Ruvalcaba

Cancer-causing gene activity is detailed  -  Sep 18, 2007
Science Daily (press release)2004) -- Scientists from MIT's Center for Cancer Research have developed a new mouse model that closely resembles Li-Fraumeni Syndrome (LFS) in humans,

Background information on Li-Fraumeni Syndrome [When available]

Li-Fraumeni syndrome is a rare autosomal dominant hereditary disorder. It is named after Frederick Pei Li and Joseph F. Fraumeni, American physicians who originally described the syndrome. It increases greatly the susceptibility to cancer. The syndrome is a mutation in the p53 tumor suppressor gene, which normally helps control cell growth.

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