Gestational Trophoblastic Disease

This page contains recent news articles, when available, and an overview of Gestational Trophoblastic Disease but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Gestational Trophoblastic Disease

Mildred R. Chernofsky, MD joins Sibley's Gynecologic Oncology and ...  -  ‎Jul 13, 2009‎
PRLog.Org (press release)...preinvasive and invasive disease of the vulva, vagina and cervix, gestational trophoblastic disease, and advanced laparoscopic and robotic surgery.

Professor retires after 35 years caring for patients  -  ‎Jul 17, 2009‎
The StarHe is an expert in lymphoma, gestational trophoblastic disease, and biological therapy, has authored or edited eight books including Cancer Care in the

A miracle for Christmas  -  Dec 25, 2008
Asbury Park Press,It was a rare, rapid-growing type called Gestational Trophoblastic Disease, or GTD. It occurs, for reasons unknown, after conception when the uterine cells

Voiceless and Abused  -  Nov 10, 2008
Seattle Post IntelligencerSoon after that, doctors diagnosed Jamie with gestational trophoblastic disease, a serious medical condition in which benign tumors develop from placental

Problems seen in postnatal period  -  Dec 18, 2007
New Zealand Doctor Online,Histology of the “products� should be requested to exclude gestational trophoblastic disease. For breast infections, flucloxacillin is indicated early to

Woman's love and inspiration will live on  -  Oct 11, 2007
KC Community News,Danette was featured in The Sun last February, in an article highlighting her optimism and fortitude as she battled gestational trophoblastic disease,



Background information on Gestational Trophoblastic Disease [When available]

Gestational trophoblastic disease — usually referred to as a mole — is a very rare abnormality of pregnancy in the reproductive female that involves abnormal trophoblast proliferation. It is the result of a (purely chance) genetic error during the fertilization process that in turn causes the growth of abnormal tissue (which is not an embryo) within the uterus. The growth of this material is disproportionately rapid when compared to normal fetal growth.

The two types of hydatidiform molar pregnancy are complete and partial.

Complete moles are the most common type of moles, and are when the mass of tissue is completely made up of abnormal cells that would have become the placenta in a normal pregnancy. There is no fetus and nothing can be found at the time of the first scan. Complete moles often have a diploid karyotype 46,XX due to fertilization of an empty ovum by a single sperm followed by replication of the haploid chromosome. On ultrasound, a complete mole has a "snow storm pattern", and the uterus is large for dates. Microscopically, there is edema of most villi, which gives the appearance of a large and random collection of grape-like cell clusters.

In a partial mole, the mass may contain both these abnormal cells and often a fetus that has severe defects. In this case, the fetus will be consumed by the growing abnormal mass very quickly. Partial moles have a triploid karyotype (69,XXX or 69,XXY) due to the fertilization of a single egg with two sperm. They also have a lower volume of tissue, and smaller hydropic villi (grape-like), as well as normal villi mixed in with the abnormal. Rarely, partial moles can progress to gestational choriocarcinoma.

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