Chronic Myeloproliferative Disorders

This page contains recent news articles, when available, and an overview of Chronic Myeloproliferative Disorders but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Chronic Myeloproliferative Disorders

S*BIO's Oral JAK2 Inhibitor SB1518 Demonstrates Therapeutic ...  -  Dec 10, 2007
Earthtimes,JAK2 is the most common mutated gene in bcr-abl-negative chronic myeloproliferative disorders (MPDs). SB939, a novel histone deacetylase HDAC inhibitor with



Background information on Chronic Myeloproliferative Disorders [When available]

The myeloproliferative diseases are a group of diseases of the bone marrow where excess cells are produced. The delineation from leukemia is artificial, although the myeloproliferative diseases on the whole have a much better prognosis than the leukemias. The concept was first proposed in 1951 by the eminent hematologist William Dameshek.

The myeloproliferative diseases are:
  • Chronic myelogenous leukemia (CML)
  • Polycythemia vera (PCV)
  • Essential thrombocytosis (ET)
  • Myelofibrosis (increased connective tissue with decreased room for production of normal blood cells).
All MPDs arise from precursors of the "myeloid" lineage in the bone marrow. The lymphoid lineage may produce similar diseases, the lymphoproliferative disorders (acute lymphoblastic leukemia, lymphomas, chronic lymphocytic leukemia and multiple myeloma).

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