Amyloid

This page contains recent news articles, when available, and an overview of Amyloid but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

News: Amyloid

Alzheimer's: Destructive Amyloid-Beta Protein May Also Be Essential for Normal ...  -  23 Nov 2009
Science Daily (press release)23, 2009) — Alzheimer's disease is thought to be caused by the build-up of a brain peptide called amyloid-beta. That's why eliminating the protein has been ...

Alzheimer's research at the University of Louisville  -  23 Nov 2009
Louisville Courier-JournalThey injected that potato virus protein into mice and found it produced antibodies that could attach to amyloid beta protein. UofL researchers Friedland and ...

SLU Researchers to Test Gammaglobulin for Alzheimer's Disease  -  23 Nov 2009
Saint Louis UniversityInvestigators will examine whether IGIV, which is made from the blood of several thousand healthy adults and contains naturally occurring human anti-amyloid ...

Research from University of California, Department of Neurosciences provides ...  -  23 Nov 2009
Behavioral Health Central (blog)While progressive accumulation of oligomeric amyloid-beta protein (Abeta) has been identified as one of the central toxic events in AD leading to synaptic ...

Recovery Funds Advance Alzheimer's Disease Research  -  23 Nov 2009
National Institutes of Health (press release)...stages of Alzheimer's disease sooner and more accurately by measuring levels of two biomarkers — tau and beta-amyloid proteins — in cerebrospinal fluid. ...

Surprising superfoods  -  23 Nov 2009
The AgeResults from a new laboratory study, published earlier this month, suggest it may also slow the formation of the amyloid plaques associated with Alzheimer's ...

Raising Alzheimer's Disease Awareness with an Apple a Day  -  23 Nov 2009
PR Web (press release)¹Chan, A and Shea, T. Dietary Supplementation with Apple Juice Decreases Endogenous Amyloid-B2 Levels in Murine Brain. Journal of Alzheimer's Disease, 2009; ...

Protein Changes in Heart Strengthen Link Between Alzheimer's Disease and ...  -  ‎Nov 15, 2009‎
Science Daily (press release)The changes led to the formation of debris-like protein clusters, or amyloid-like oligomers containing desmin, in heart muscle, similar to the amyloid ...

An Atomic-Level Look at an HIV Accomplice  -  ‎Nov 20, 2009‎
Science Daily (press release)Individual PAP248-286 peptides have a tendency to clump together to form amyloid fibers called SEVI (semen enhancer of viral infection). ...

Matters of the mind  -  ‎Nov 21, 2009‎
Norristown Times HeraldBut it has been known for over 100 years now that the main change in the brain is the accumulation of a sticky protein called amyloid. ...

Amyloid Beta Protein Gets Bum Rap  -  ‎Nov 9, 2009‎
Science Daily (press release)10, 2009) — While too much amyloid beta protein in the brain is linked to the development of Alzheimer's disease, not enough of the protein in healthy ...

Expression of complement system components during aging and amyloid deposition ...  -  ‎Nov 17, 2009‎
7thSpace Interactive (press release)However, histological studies of amyloid plaque bearing APP transgenic mice provided only evidence for an activation of the early parts of the complement ...

Bayer HealthCare Presents Florbetaben Phase II Study Results at World Congress ...  -  ‎Oct 30, 2009‎
ReutersCerebral beta-Amyloid plaques are one of the pathological hallmarks of Alzheimer's disease. Current diagnosis of Alzheimer's disease is based on cognitive ...

Mouse gene suppresses Alzheimer's plaques and tangles  -  ‎Nov 11, 2009‎
EurekAlert (press release)The amyloid and tau lowering functions of this gene were demonstrated in both human and mouse cells. Amyloid beta is responsible for the plaques found in ...

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle  -  ‎Nov 12, 2009‎
Science Magazine (subscription)Chronic sleep restriction significantly increased, and a dual orexin receptor antagonist decreased, Aβ plaque formation in amyloid precursor protein ...

Hybrid molecules may treat Alzheimer's  -  ‎Nov 5, 2009‎
United Press InternationalThe researchers, led by Professor Mi Hee Lim, said one of the mysteries of Alzheimer's disease is how protein-like snippets called amyloid-beta peptides can ...

Protein changes in heart may strengthen link between Alzheimer and chronic ...  -  ‎Nov 21, 2009‎
HealthJockey.comThe changes could perhaps lead to the development of debris-like protein clusters similar to the amyloid plaques seen in the brain tissue of Alzheimer's ...

Promedior Announces Publication of Preclinical Studies in Science ...  -  ‎Nov 4, 2009‎
ReutersPromedior`s lead product candidate, PRM-151 (rhSAP), is a recombinant form of human Serum Amyloid P, a highly conserved natural human serum protein that ...

Alzheimer's research goes against past beliefs  -  ‎Nov 12, 2009‎
Belleville News DemocratDoctors have long believed that too much of a substance in the brain known as beta amyloid protein can lead to the development of Alzheimer's disease. ...

Codistribution of Amyloid β Plaques and Spongiform Degeneration in Familial ...  -  ‎Nov 9, 2009‎
Archives of NeurologyCoexistent amyloid β (Aβ) plaques have been reported in some transmissible spongiform encephalopathies but to date have not been reported in familial CJD ...

Hybrid Molecules Show Promise For Exploring, Treating Alzheimer's  -  ‎Nov 4, 2009‎
Science Daily (press release)4, 2009) — One of the many mysteries of Alzheimer's disease is how protein-like snippets called amyloid-beta peptides, which clump together to form plaques ...

Serum Amyloid P Inhibits Fibrosis Through FcγR-Dependent Monocyte-Macrophage ...  -  ‎Nov 4, 2009‎
Science Magazine (subscription)Serum amyloid P is a naturally circulating soluble pattern recognition receptor, a member of the family of pentraxin proteins. It links danger-associated ...

Latest mouse gene seems to lessen plaques and tangles in Alzheimer disease  -  ‎Nov 18, 2009‎
HealthJockey.comApparently, these toxic proteins namely amyloid beta and tau are major players in Alzheimer's disease. The findings could perhaps lead to novel treatments ...

Characterization of the amyloid bacterial inclusion bodies of the HET-s fungal ...  -  ‎Oct 28, 2009‎
7thSpace Interactive (press release)The formation of amyloid aggregates is related to the onset of a number of human diseases. Recent studies provide compelling evidence for the existence of ...

Adeona Pharmaceuticals Announces Third Quarter 2009 Results and Achievements  -  ‎Nov 17, 2009‎
CNNMoney.com (press release)Sparks D. and Schreurs, B., Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. ...

Alzheimer's disease strikes people with Down syndrome  -  ‎Nov 20, 2009‎
YourWestValley.comSabbagh said one of the key proteins found in Alzheimer's patients — beta amyloid — is found on the gene on chromosome 21 — whose over-expression causes ...

Mouse Gene Suppresses Alzheimer's Plaques and Tangles  -  ‎Nov 16, 2009‎
OBBeC.comThe amyloid and tau lowering functions of this gene were demonstrated in both human and mouse cells. Amyloid beta is responsible for the plaques found in ...

Adeona Launches CopperProof Test Panel  -  ‎Nov 9, 2009‎
CNNMoney.com (press release)Sparks D. and Schreurs, B., Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. ...

Critical thinking and creativity in AD research  -  ‎Nov 9, 2009‎
Gerson Lehrman Group...plaque removal is not enough to halt progressive neurodegeneration in Alzheimer Disease and prompt some intriguing challenges to the amyloid hypothesis. ...

Olive oil: An anti-Alzheimer fat  -  ‎Nov 17, 2009‎
St. Catharines StandardThese senile plaques are caused by the excessive secretion and aggregation of a protein called beta amyloid that provokes the formation of insoluble ...

Red wine compound slows brain plaque linked to Alzheimer's disease, study finds.  -  ‎Nov 6, 2009‎
Environmental Health NewsA compound in red wine may offer yet another health benefit – it may slow formation of the amyloid plaques associated with Alzheimer's disease. ...

Curry spice 'kills cancer cells'  -  ‎Oct 29, 2009‎
The National OnlineCurcumin appears to prevent the spread of amyloid protein plaques – thought to cause dementia – in the brain. Amyloid plaques, along with tangles of nerve ...

New Alzheimer's Drugs Show Promise, Say UAB Researchers  -  ‎Nov 3, 2009‎
UAB NewsAlzheimer's is marked by the presence of amyloid plaques in the brain. Amyloid is a starchy like substance which, when abnormally deposited in the brain, ...

Eyes may hold clue to early Alzheimer's diagnosis  -  ‎Nov 7, 2009‎
The Virtual Medical Centre...have found that the changes that take place in Alzheimer's disease brains also occur in retinas, including the accumulation of amyloid plaque lesions. ...

Senexis files new patents to protect novel Alzheimer's compounds  -  ‎Nov 15, 2009‎
Cambridge NetworkIt is now widely believed that the misfolding and aggregation of amyloid-like proteins underlies the pathologies of Alzheimer's and Senexis has discovered ...

A fix for Down syndrome brains?  -  ‎Nov 18, 2009‎
ScientistThis link may arise via the gene App on chromosome 21, which codes for the amyloid precursor protein. This protein can form the amyloid plaques associated ...

VC winner named among West's top Aussies  -  ‎Nov 21, 2009‎
NEWS.com.auHis team made a significant discovery showing that beta amyloid protein which coats the brain is the foundation of the debilitating disease. ...

Scientists Find Molecular Trigger That Helps Prevent Aging and Disease  -  ‎Nov 18, 2009‎
Science Daily (press release)In these types of roundworms, human beta amyloid peptide, which contributes to plaque buildup in Alzheimer's disease, is expressed in muscle, which becomes ...

This Month in Archives of Neurology  -  ‎Nov 9, 2009‎
Archives of Neurology...observation that cellular prion protein (PrP c ) is a high-affinity receptor for β-amyloid oligomers, mediating their toxicity on synaptic plasticity. ...

Probiodrug Gets €36M for Novel Alzheimer's Program  -  ‎Nov 3, 2009‎
BioWorld OnlineMost current late-stage clinical development programs are focused on disrupting the formation of amyloid beta (Abeta) peptide and its aggregation and ...

High Protein Diets may Lead to Brain Shrinkage  -  ‎Nov 1, 2009‎
Natural News.com (registration)With this in mind, researchers put four specific diets to the test to see how, or if, they contributed to the formation of amyloid proteins in the brain. ...

Learning to live with rare disease  -  ‎Oct 31, 2009‎
Dickinson PressAmyloid is an abnormal protein produced by cells in the bone marrow that can be deposited in any tissue or organ. Primary amyloidosis happens when enough ...

Drink apple juice 'to stave off Alzheimer's'  -  ‎Oct 31, 2009‎
Press Trust of India...called "beta-amyloid" that is responsible for forming the "senile plaques" that are commonly found in brains of individuals suffering from Alzheimer's.

"Worms, Coffee, Alzheimers and Parkinsons"  -  ‎Nov 5, 2009‎
Colorado State University (press release)A major component of senile plaques is the beta amyloid peptide, and genetic evidence suggests this peptide is centrally involved in AD pathology. ...

Functional Genetics Announces Discovery of Target That Regulates Alzheimer's ...  -  ‎Nov 15, 2009‎
PR-USA.net (press release)Amyloid beta is responsible for the lesions found in the brains of Alzheimer's patients. Tau causes the tangles that typify the disease in patients' brain ...

Lankenau Institute Investigators Discover a Potential New Antibody Therapy to ...  -  ‎Nov 11, 2009‎
PR-USA.net (press release)The study showed that the monoclonal F1 heavy chain (HC) prevented in vitro amyloid beta fibril growth and protected rodent brain cells involved in learning ...

Marcial: Is Eli Lilly Ripe for a Rebound?  -  ‎Nov 10, 2009‎
BusinessWeek..."You could double your money in the stock if, for instance, Lilly's Solanezumab—an anti-amyloid monoclonal antibody aimed at delaying the progression of ...

Gene may envisage threat of Alzheimer disease symptoms post traumatic brain ...  -  ‎Oct 28, 2009‎
HealthJockey.comAmyloid plaque deposits, known mainly for their function in Alzheimer's disease, are apparently discovered in almost one third of people who die from severe ...

Inflammation, Genes, and Hypertension All Contribute to Alzheimer's Risk  -  ‎Nov 2, 2009‎
U.S. News & World Report...didn't have parents with the disease. High blood pressure appears to speed the development of beta amyloid plaque in the brain, a hallmark of Alzheimer's.

Mayo Clinic Licenses Expression Pathology Technology for MS-based Amyloidosis ...  -  ‎Nov 18, 2009‎
GenomeWeb Daily NewsAmyloidosis is a condition in which amyloid proteins build up in organs. It is characterized by organ function impairment, and subtyping of the disease is ...



Background information on Amyloid [When available]

Amyloid describes various types of protein aggregations that share specific traits when examined microscopically. The name amyloid comes from the early mistaken identification of the substance as starch (amylum in Latin), based on crude iodine-staining techniques. For a period the scientific community debated whether or not amyloid deposits were fatty deposits or carbohydrate deposits until it was finally resolved that it was neither, rather a deposition of proteinaceous mass.

The phenotypes of genetically transmitted amyloid diseases are often inherited in an autosomal dominant fashion. Sometimes, the difference between aggressive amyloid diseases and senescent amyloid diseases is due to a mutation which makes the protein more prone to aggregation. Most commonly seen are point mutations which affect the cohesiveness of the protein and promote misfolding; other mutations cause aggregation-prone pieces of the protein to be cleaved off from the rest of the protein.

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